SCNS.02. Evaluation of xanthine oxidase enzyme inhibition in a model of depressivelike behavior induced by LPS in mice

SCNS.02. Evaluation of xanthine oxidase enzyme inhibition in a model of depressivelike behavior induced by LPS in mice

TOMAZ, V.S.; CORDEIRO, R.C.; MONTEIRO, I.O.; MACEDO, D.

Abstract:

The participation of nitric oxide (NO) in the pathophysiology of depression has been extensively studied, suggesting an important role of this gas in depression. Several inhibitors of nitric oxide synthase (NOS) were considered potent antidepressant agents. The xanthine oxidase (XO) in hypoxic conditions and in the presence of NADH is able to catalyze organic nitrates into NO, thereby the inhibition of this enzyme reduces the availability of NO in organisms. Based on this hypothesis we evaluated the inhibition of XO as an indirect way to observe the role of NO in an experimental model of depressive-like behavior.

The participation of nitric oxide (NO) in the pathophysiology of depression has been extensively studied, suggesting an important role of this gas in depression. Several inhibitors of nitric oxide synthase (NOS) were considered potent antidepressant agents. The xanthine oxidase (XO) in hypoxic conditions and in the presence of NADH is able to catalyze organic nitrates into NO, thereby the inhibition of this enzyme reduces the availability of NO in organisms. Based on this hypothesis we evaluated the inhibition of XO as an indirect way to observe the role of NO in an experimental model of depressive-like behavior.

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DOI: 10.5151/isnm-sine7

Como citar:

TOMAZ, V.S.; CORDEIRO, R.C.; MONTEIRO, I.O.; MACEDO, D.; "SCNS.02. Evaluation of xanthine oxidase enzyme inhibition in a model of depressivelike behavior induced by LPS in mice", p-12-12. In: In I International Symposium in Neuroscience Meeting, 2013 [Blucher Neuroscience Proceedings n.1 v.1]. São Paulo: Blucher, 2014.
ISSN 2357772x, DOI 10.5151/isnm-sine7