Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Studies toward total synthesis of tautomycetin

Sant’Ana, Danilo P. ; Fiqueiredo, Renata Marcia de ; Campagne, Jean-Marc ; Dias., Luiz Carlos ;

Abstract:

Tautomycetin is a polyketide natural product recognized as an inhibitor of serine/threonine phosphatases type I. In spite of this important activity, there is no total synthesis described in the literature. For this reason, we have proposed a project aiming to the total synthesis of tautomycetin. We wish to describe here our approach to fragments C7’-17 and C1-C12 of tautomycetin.

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Palavras-chave: total synthesis, tautomycetin, phosphatases,

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013818172811

Referências bibliográficas
  • [1] 1 Sakoff, J. A. ; McCluskey, A. Curr. Pharm. Des. 2004, 10, 1139.
  • [2] 2 Oikawa, H. Curr. Med. Chem. 2002, 9, 2033.
  • [3] 3 Negishi, E. ARKIVOC 2011, 34.
Como citar:

Sant’Ana, Danilo P.; Fiqueiredo, Renata Marcia de; Campagne, Jean-Marc; Dias., Luiz Carlos; "Studies toward total synthesis of tautomycetin", p. 163 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_2013818172811

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