Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Study toward the convergent total synthesis of the aporphine alkaloid PO-3

Rossini, Allan F. C. ; Raminelli, Cristiano ;

Abstract:

Due to the great importance of benzyne as a highly reactive intermediate in organic chemistry, with applications in total syntheses and in preparations of functional materials, we intend to accomplish the convergent total synthesis of the aporphine alkaloid PO-3 (1), a natural dye of green color, employing as key reaction a [4+2] cycloaddition between 1-methylene-1,2,3,4-tetrahydroisoquinoline (3) and the benzyne derivative 7, formed from 2-(trimethylsilyl)aryl triflate (8), under mild reaction conditions.

Abstract:

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Palavras-chave: benzyne chemistry, aporphine alkaloid, cycloaddition reaction,

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DOI: 10.5151/chempro-15bmos-BMOS2013_201392135541

Referências bibliográficas
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  • [4] 4Singh, O. V.; Huang, W.-J; Chen, C.-H.; Lee, S.-S. Tetrahedron Lett. 2007, 48, 8166.
Como citar:

Rossini, Allan F. C.; Raminelli, Cristiano; "Study toward the convergent total synthesis of the aporphine alkaloid PO-3", p. 106 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_201392135541

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