Synthesis of fluorinated aminosugars Positron Emission Tomography diagnostic studies

Synthesis of fluorinated aminosugars Positron Emission Tomography diagnostic studies

Nunes, Paulo Sérgio Gonçalves; Bernades, Emerson Soares; Carvalho, Ivone

Abstract:

Aminosugars are widely spread carbohydrates in organisms, which participate in cell reorganization and signaling. The involvement of these molecules in a vast variety of processes has led researches to explore their synthesis. In this work, we developed a route to prepare fluorinated 2-acetamido-2-deoxy derivatives (Fig. 1), with potential application in 18F radiolabeled sugars in cancer diagnosis and for cell mechanisms studies by Positron Emission Tomography (PET).

Aminosugars are widely spread carbohydrates in organisms, which participate in cell reorganization and signaling. The involvement of these molecules in a vast variety of processes has led researches to explore their synthesis. In this work, we developed a route to prepare fluorinated 2-acetamido-2-deoxy derivatives (Fig. 1), with potential application in 18F radiolabeled sugars in cancer diagnosis and for cell mechanisms studies by Positron Emission Tomography (PET).

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_201382016345

Referências bibliográficas

• [1] 1Varki, A. et al. (Org.). 2. ed Essentials of Glycobiology. New York: Cold Spring Harbor Laboratory Press, 2009.

Como citar:

Nunes, Paulo Sérgio Gonçalves; Bernades, Emerson Soares; Carvalho, Ivone; "Synthesis of fluorinated aminosugars Positron Emission Tomography diagnostic studies", p-54-54. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201382016345