Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Synthesis of New Mitotane Analogues

Santana, Amanda S. ; Sampaio, Felipe R. ; Correia, Carlos Roque D. ;

Abstract:

Mitotane (1) is a therapeutic agent used in the treatment of a rare type of carcinoma of the adrenal cortex. This cancer affect children particularly in the states of Paraná and São Paulo. Despite its proven therapeutic efficacy, the mitotane 1, a chemical congener of the insecticide DDT (2), has high toxicity. It is believed that its toxicity is associated with the formation of the corresponding acid chloride in the body. Thus, this work aims at preparing new mitotane analogues that might have reduced toxicity.

Abstract:

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Palavras-chave: Heck-Matsuda reaction, medicinal chemistry, gram scale,

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013914141646

Referências bibliográficas
  • [1] 1 AMA Council Report. Guidelines for Handling Parenteral Antineoplastics.
  • [2] JAMA, March 15, 1985.
  • [3] 2 Figueiredo, B. C.; Sandrini, R.; Ribeiro, R. C.; Lacerda, L.; Pianovski, M.
  • [4] D. Tumores de Córtex Adrenal, 2004, 2a ed. Governo do Paraná.
  • [5] 3 (a) J. C. Pastre, C. R. D. Correia, Adv. Synth. Catal. 2009, 351, 1217. (b)
  • [6] J. G. Taylor, C. R. D. Correia, J. Org. Chem. 2011, 76, 857. (c) Pastre, J.
  • [7] C.; Correia, C. R. D. Org. Lett. 2006, 8, 165.
Como citar:

Santana, Amanda S.; Sampaio, Felipe R.; Correia, Carlos Roque D.; "Synthesis of New Mitotane Analogues", p. 241 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_2013914141646

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