Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

Abstract - Open Access.

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Synthesis of novel amides derived from lumisantonin

Moraes, Fernanda C. ; Alvarenga, Elson S. ; Amorim, Kariny B. ;

Abstract:

Sesquiterpene lactones are present in many medicinal natural sources and exhibit a variety of biological activities. As part of our current synthetic programme related to natural sesquiterpenes with biological activity, we have synthesized a series of (2S)-N-alkyl-2-((3aR,3bS,6S,7S)-7-hydroxy-3a,3b-dimethyl-3-oxo-3a,3b,4,5,6,7-hexahydro-3H-cyclo penta[1,3]cyclopropa[1,2]benzen-6-yl)propanamide from lumisantonin which was prepared from the widely available α-santonin.

Abstract:

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Palavras-chave: lumisantonin, amides, sesquiterpene lactones,

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DOI: 10.5151/chempro-15bmos-BMOS2013_201391315423

Referências bibliográficas
  • [1] 1 Macías, A. F.; Fernandes S A.; Varela, R. M.; Molinillo, J. M. G.; Torres, A.; Alves, P. L. C. A. J. Nat. Prod., v.69, p. 795-800, 2006.
  • [2] 2 Hu, D; Wan, Q; Yang, S; Bhadury, P, S; Jin, L; Yan, K; Liu, F; Chen, Z; Xue, W. J. Agric. Food Chem. v. 56, 998–1001, 2008.
  • [3] 3 Barton, D. H. R.; Miki, T.; Pinhey, J. T.; Wells, R. J.; Proc. Chem. Soc. 1962, 112.
Como citar:

Moraes, Fernanda C.; Alvarenga, Elson S.; Amorim, Kariny B.; "Synthesis of novel amides derived from lumisantonin", p. 74 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_201391315423

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